Cognitive framing modulates emotional processing through dorsolateral prefrontal cortex and ventrolateral prefrontal cortex networks: A functional magnetic resonance imaging study
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Cognitive framing modulates emotional processing through dorsolateral prefrontal cortex and ventrolateral prefrontal cortex networks: A functional magnetic resonance imaging study. / Kirk, Ulrich; Lilleholt, Lau; Freedberg, David .
In: Brain and Behavior, Vol. 10, No. 9, e01761, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cognitive framing modulates emotional processing through dorsolateral prefrontal cortex and ventrolateral prefrontal cortex networks: A functional magnetic resonance imaging study
AU - Kirk, Ulrich
AU - Lilleholt, Lau
AU - Freedberg, David
PY - 2020
Y1 - 2020
N2 - Introduction: In this study, we show new evidence for the role of ventrolateral prefrontal cortex-dorsolateral prefrontal cortex (VLPFC-DLPFC) networks in the cognitive framing of emotional processing. Method: We displayed neutral and aversive images described as having been sourced from artistic material to one cohort of subjects (i.e., the art-frame group;n = 19), while identical images, this time identified as having been sourced from documentary material (i.e., the doc-frame group;n = 20) were shown to a separate cohort. Results: Using functional magnetic resonance imaging (fMRI), we employed a linear parametric model showing that relative to the doc-frame group the art-frame group exhibited a modulation of amygdala activity in response to aversive images. The attenuated amygdala activity in the art-frame group supported our hypothesis that reduced amygdala activity was driven by top-down DLPFC inhibition of limbic responses. A psychophysiological interaction (PPI) analysis demonstrated that VLPFC activity correlated with amygdala activity in the art-frame group, but not in the doc-frame group for the contrast [Aversive > Neutral]. Conclusion: The role of the VLPFC in cognitive control suggests the hypothesis that it alongside DLPFC insulates against embodied emotional responses by inhibiting automatic affective responses.
AB - Introduction: In this study, we show new evidence for the role of ventrolateral prefrontal cortex-dorsolateral prefrontal cortex (VLPFC-DLPFC) networks in the cognitive framing of emotional processing. Method: We displayed neutral and aversive images described as having been sourced from artistic material to one cohort of subjects (i.e., the art-frame group;n = 19), while identical images, this time identified as having been sourced from documentary material (i.e., the doc-frame group;n = 20) were shown to a separate cohort. Results: Using functional magnetic resonance imaging (fMRI), we employed a linear parametric model showing that relative to the doc-frame group the art-frame group exhibited a modulation of amygdala activity in response to aversive images. The attenuated amygdala activity in the art-frame group supported our hypothesis that reduced amygdala activity was driven by top-down DLPFC inhibition of limbic responses. A psychophysiological interaction (PPI) analysis demonstrated that VLPFC activity correlated with amygdala activity in the art-frame group, but not in the doc-frame group for the contrast [Aversive > Neutral]. Conclusion: The role of the VLPFC in cognitive control suggests the hypothesis that it alongside DLPFC insulates against embodied emotional responses by inhibiting automatic affective responses.
KW - Faculty of Social Sciences
KW - amygdala
KW - dorsolateral prefrontal cortex
KW - emotion
KW - framing
KW - functional magnetic resonance imaging
KW - ventrolateral prefrontal cortex
U2 - 10.1002/brb3.1761
DO - 10.1002/brb3.1761
M3 - Journal article
C2 - 32749046
VL - 10
JO - Brain and Behavior
JF - Brain and Behavior
SN - 2157-9032
IS - 9
M1 - e01761
ER -
ID: 251188505