In certain societies that promote extreme social inequalities, a group of dominant elites deploys instruments designed to control marginalized group members through propaganda, by diminishing their self-worth, and by instilling a sense of being unworthy of the respect (dignity) of others. These instruments may appear innocuous, as when civil-society leaders render “reasonable” decisions, government officials establish “essential” directives, and bureaucrats implement “common sense” policies. But their effect is to promote the collective suffering of marginalized people. In this chapter, we examine the dynamics of systemic humiliation through the use of five instruments: (1) laws that unjustly favor social elites, (2) an ideology of supremacy that rationalizes such laws, (3) a language that essentializes the degraded people, (4) images that reinforce such a status, and (5) means to erase the achievements and capacities of these people. Drawing upon recent developments in social identity theory, moral philosophy, sociological theory, and clinical psychology, we argue that systemic humiliation generates social pain that is experienced as annulment of one’s inherent value; it is an affront to suffering persons’ moral selves. Mitigation of systemic humiliation is particularly challenging, as it operates without easily identifiable agents/humiliators. We conclude with preliminary recommendations regarding the need to adopt multiple perspectives to alleviate suffering caused by such humiliation.