TY - JOUR

T1 - The Effects of Exercise on Cognitive Recovery after Acquired Brain Injury in Animal Models

T2 - A Systematic Review

AU - Wogensen, Elise

AU - Rytter, Hana Malá

AU - Mogensen, Jesper

PY - 2015/10/6

Y1 - 2015/10/6

N2 - The objective of the present paper is to review the current status of exercise as a tool to promote cognitive rehabilitation afteracquired brain injury (ABI) in animal model-based research. Searches were conducted on the PubMed, Scopus, and psycINFOdatabases in February 2014. Search strings used were: exercise (and) animal model (or) rodent (or) rat (and) traumatic brain injury(or) cerebral ischemia (or) brain irradiation. Studies were selected if they were (1) in English, (2) used adult animals subjectedto acquired brain injury, (3) used exercise as an intervention tool after inflicted injury, (4) used exercise paradigms demandingmovement of all extremities, (5) had exercise intervention effects that could be distinguished from other potential interventioneffects, and (6) contained at least one measure of cognitive and/or emotional function. Out of 2308 hits, 22 publications fulfilled thecriteria.The studies were examined relative to cognitive effects associated with three themes: exercise type (forced or voluntary),timing of exercise (early or late), and dose-related factors (intensity, duration, etc.).The studies indicate that exercise in many casescan promote cognitive recovery after brain injury. However, the optimal parameters to ensure cognitive rehabilitation efficacy stillelude us, due to considerable methodological variations between studies.

AB - The objective of the present paper is to review the current status of exercise as a tool to promote cognitive rehabilitation afteracquired brain injury (ABI) in animal model-based research. Searches were conducted on the PubMed, Scopus, and psycINFOdatabases in February 2014. Search strings used were: exercise (and) animal model (or) rodent (or) rat (and) traumatic brain injury(or) cerebral ischemia (or) brain irradiation. Studies were selected if they were (1) in English, (2) used adult animals subjectedto acquired brain injury, (3) used exercise as an intervention tool after inflicted injury, (4) used exercise paradigms demandingmovement of all extremities, (5) had exercise intervention effects that could be distinguished from other potential interventioneffects, and (6) contained at least one measure of cognitive and/or emotional function. Out of 2308 hits, 22 publications fulfilled thecriteria.The studies were examined relative to cognitive effects associated with three themes: exercise type (forced or voluntary),timing of exercise (early or late), and dose-related factors (intensity, duration, etc.).The studies indicate that exercise in many casescan promote cognitive recovery after brain injury. However, the optimal parameters to ensure cognitive rehabilitation efficacy stillelude us, due to considerable methodological variations between studies.

KW - Faculty of Social Sciences

KW - hjerneskade

KW - hjernens plasticitet

KW - Neurobiology. gene ekspression

KW - Neurorehabilitering

KW - Funktionel genopretning

KW - Motion

KW - dyremodel

KW - BDNF

KW - neurotrofiner

KW - adfærd

KW - kognition

U2 - 10.1155/2015/830871

DO - 10.1155/2015/830871

M3 - Journal article

C2 - 26509085

VL - 2015

SP - 1

EP - 22

JO - Neural Plasticity

JF - Neural Plasticity

SN - 2090-5904

M1 - 830871

ER -